NIH Sponsored Study at Stanford University School of Medicine to Utilize Fluidigm Mass Cytometry Technology and Maxpar Direct Immune Profiling Assay to Evaluate Immune Responses in Pediatric Patients with COVID-19
Study Exemplifies Increasing Use of CyTOF Technology in Clinical Research
The study on immune system activity in SARS-CoV-2 positive children, Pediatric Research Immune Network on SARS-CoV-2 and MIS-C (PRISM) (NCT04588363), will compare data from those with asymptomatic infections, mild COVID-19 and multisystem inflammatory syndrome (MIS-C). A goal of the PRISM study is to characterize the immunologic pathways associated with different disease presentations and outcomes.
Krams is a lead researcher on the study, along with
“Little is known about the immunologic mechanisms and characteristics associated with different forms of MIS-C and COVID-19 in children,” Krams said. “The study aims to fill gaps in understanding the clinical spectrum of COVID-19 in children and young adults, the long-term outcomes of SARS-CoV-2 infection in these populations and the underlying immunologic basis of MIS-C. This knowledge could be extremely valuable in preventing, managing and developing effective therapies for this dangerous consequence of SARS-CoV-2 infection.”
The study is expected to enroll about 250 SARS-CoV-2 infected patients under age 21 from diverse racial and ethnic backgrounds. Blood samples will be collected at 20 clinical sites and will be sent to
The study will utilize Fluidigm’s unique Cell-ID™ 20-Plex Pd Barcoding Kit to allow up to 20 tests to be performed in a single run. Fluidigm’s automated Maxpar Pathsetter™ and debarcoding software will be used to analyze the data generated with the assay.
Blood samples will be collected from each patient four times over the course of a year in order to evaluate changes in immune system activity and correlate this activity with each patient’s COVID-19 status and clinical experience.
“We are gratified that our suite of mass cytometry and Maxpar technologies is helping to advance our understanding of COVID-19 and will provide researchers and clinicians with information that can help improve management, treatment and outcomes for patients with the disease,” said
“Data from this study will join a growing body of peer-reviewed research based on mass cytometry and Maxpar technologies. That research includes a recent study that identified a distinct phenotype in patients with severe COVID-19, as well as an ongoing
Two other National Clinical Trials are also employing the Maxpar assay:
- COvid-19 Advanced Genetic and Immunologic Sampling (COntAGIouS), NCT04327570, has the goal of identifying factors that result in hypersusceptibility to SARS-CoV-2 infection.
- Antidepressant Trial with P2X7 Antagonist JNJ-54175446 (ATP), NCT04116606, is designed to assess changes in peripheral blood immune cell populations at baseline and after treatment.
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Source: Fluidigm Corporation