CyTOF and Maxpar Direct Technologies Utilized in Study Characterizing Immune and Inflammatory Responses in Pregnant Women Infected with SARS-CoV-2
Findings in Nature Communications Provide Insights That May Help Guide
Research Study Conducted in Collaboration with Fluidigm’s Therapeutic Insights Services
The recently published study in
Researchers at the
“These results are the first to characterize the immune profiles and activity of asymptomatic or paucisymptomatic pregnant women infected with SARS-CoV-2 and to compare them with profiles from uninfected pregnant women and controls,” said Andrea Cossarizza, MD, PhD, Professor of Pathology, Immunology and Clinical Immunology at the
Hormonal changes result in the immune system taking on more anti-inflammatory characteristics during pregnancy. It is unclear whether these changes increase the risk of pregnant women becoming infected with SARS-CoV-2 due to potentially lower immune system reactivity, or whether the reduced inflammatory activity may help to reduce the risk of cytokine storm associated with severe COVID-19 disease. As part of the study, researchers used the Maxpar Direct Immune Profiling Assay, six additional
- Evaluation of 62 cytokines in 14 infected pregnant women, 28 uninfected pregnant women and 15 age-matched women who were not pregnant (controls) found that pregnant women generally had more anti-inflammatory cytokine profiles compared with controls, and that this was increased in pregnant women who were infected. The authors of the study hypothesize that this anti-inflammatory profile is part of the normal process that protects the fetus from attack by the mother’s immune system, and that this may be increased in infected women to counterbalance their increased immune response to the virus.
- Mass cytometry evaluation found that, regardless of infection status, pregnant women had similar types, proportions and activities of different circulating immune cells with the exception of low-density neutrophils (LDNs), which were present at higher levels in infected pregnant women.
- Mass cytometry evaluation also found that the expression of genes that play critical roles in the development and activity of T cell subsets was similar among all three groups of women.
- T cells from infected and uninfected pregnant women were fully functional with respect to proliferation and cytokine production, with the CD4+ subset of T cells demonstrating a small but significant increase in proliferation or cell division in infected women compared with uninfected pregnant women.
- Comprehensive analyses identified highly significant correlations between the levels of LDN and multiple cytokines in infected women but not in uninfected pregnant women. Several positive correlations among plasma cytokines that were much more extensive in infected compared with uninfected pregnant women were also identified.
The authors hypothesize that the immunosuppression normally present during pregnancy may protect most pregnant women from the cytokine storm, massive immune activation and hyperinflammation associated with severe COVID-19 disease, while also protecting the fetus from the mother’s immune response to the virus.
“This publication, which is likely the first detailed immunological study of pregnant women with SARS-CoV-2 infection, is the latest of more than 30 peer-reviewed studies in 2021 alone using
Fluidigm (Nasdaq:FLDM) focuses on the most pressing needs in translational and clinical research, including cancer, immunology, and immunotherapy. Using proprietary CyTOF and microfluidics technologies, we develop, manufacture, and market multi-omic solutions to drive meaningful insights in health and disease, identify biomarkers to inform decisions, and accelerate the development of more effective therapies. Our customers are leading academic, government, pharmaceutical, biotechnology, plant and animal research, and clinical laboratories worldwide. Together with them, we strive to increase the quality of life for all. For more information, visit fluidigm.com.
For Research Use Only. Not for use in diagnostic procedures.
Information in this publication is subject to change without notice. Patent information and Limited Use Label License: Fluidigm.com/legal/notices. Trademarks:
Forward-Looking Statements for Fluidigm
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including, among others, statements regarding the potential benefits of research conducted using
We use our website (fluidigm.com), investor site (investors.fluidigm.com), corporate Twitter account (@fluidigm), Facebook page (facebook.com/Fluidigm), and LinkedIn page (linkedin.com/company/fluidigm-corporation) as channels of distribution of information about our products, our planned financial and other announcements, our attendance at upcoming investor and industry conferences, and other matters. Such information may be deemed material information, and we may use these channels to comply with our disclosure obligations under Regulation FD. Therefore, investors should monitor our website and our social media accounts in addition to following our press releases, SEC filings, public conference calls, and webcasts.
Senior Director, Corporate Communications
650 243 6621
415 389 6400
Source: Fluidigm Corporation